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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BTK
All Species:
24.85
Human Site:
S174
Identified Species:
54.67
UniProt:
Q06187
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06187
NP_000052.1
659
76281
S174
I
L
E
N
R
N
G
S
L
K
P
G
S
S
H
Chimpanzee
Pan troglodytes
XP_001139051
659
76262
S174
I
L
E
N
R
N
G
S
L
K
P
G
S
S
H
Rhesus Macaque
Macaca mulatta
XP_001103213
630
73464
P168
P
E
T
K
K
R
R
P
P
P
P
I
P
L
E
Dog
Lupus familis
XP_549139
659
76330
S174
I
L
E
N
R
N
G
S
L
K
P
G
S
S
H
Cat
Felis silvestris
Mouse
Mus musculus
P35991
659
76419
S174
I
L
E
N
R
N
G
S
L
K
P
G
S
S
H
Rat
Rattus norvegicus
Q07014
512
58642
L51
P
V
P
E
S
Q
L
L
P
G
Q
R
F
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511258
657
75937
S174
I
L
E
N
R
N
G
S
L
K
S
G
S
S
H
Chicken
Gallus gallus
Q8JH64
657
75860
S173
I
L
E
S
R
N
G
S
L
K
A
G
R
S
H
Frog
Xenopus laevis
P13116
532
59718
S71
N
F
S
D
T
I
T
S
P
Q
R
T
G
P
L
Zebra Danio
Brachydanio rerio
XP_697087
640
73807
K166
S
K
N
R
D
S
R
K
P
L
P
P
T
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08630
786
87374
S243
P
A
Q
N
S
T
R
S
I
S
P
N
S
S
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
54.4
98.9
N.A.
98.3
31.2
N.A.
93
85.5
32.6
63.4
N.A.
38.9
N.A.
N.A.
N.A.
Protein Similarity:
100
100
71.9
99.6
N.A.
99.8
48.7
N.A.
96.9
93.4
47.6
78.4
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
100
N.A.
100
0
N.A.
93.3
80
6.6
6.6
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
6.6
N.A.
93.3
86.6
20
20
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
0
0
0
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
55
10
0
0
0
0
0
0
0
0
0
0
19
% E
% Phe:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
55
0
0
10
0
55
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
55
% H
% Ile:
55
0
0
0
0
10
0
0
10
0
0
10
0
0
0
% I
% Lys:
0
10
0
10
10
0
0
10
0
55
0
0
0
0
0
% K
% Leu:
0
55
0
0
0
0
10
10
55
10
0
0
0
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
55
0
55
0
0
0
0
0
10
0
0
0
% N
% Pro:
28
0
10
0
0
0
0
10
37
10
64
10
10
19
0
% P
% Gln:
0
0
10
0
0
10
0
0
0
10
10
0
0
10
0
% Q
% Arg:
0
0
0
10
55
10
28
0
0
0
10
10
10
0
0
% R
% Ser:
10
0
10
10
19
10
0
73
0
10
10
0
55
64
0
% S
% Thr:
0
0
10
0
10
10
10
0
0
0
0
10
10
0
10
% T
% Val:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _